Puppies also need to be protected from flea and tick parasites. This is easy to do no matter what age they are. From 2 days old Advantage and Frontline Spray are safe, from 2 weeks Sentinel, from 4 weeks Capstar, from 6 weeks Revolution, from 7 weeks Advantix, from 8 weeks Frontline Plus and Advocate and over 14 weeks of age it is safe to use Comfortis,